AJND Copyright © Since 2012-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711, USA
Am J Neurodegener Dis 2012;1(2):146-151

Original Article
Amnestic mild cognitive impairment with low myocardial
metaiodobenzylguanidine uptake

Ryuji Sakakibara, Takeshi Ogata, Masayuki Haruta, Masahiko Kishi, Yohei Tsuyusaki, Akihiko Tateno, Fuyuki Tateno,
Takayuki Mouri

Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan; Information Technology System,
Sakura Medical Center, Toho University, Sakura, Japan.

Received April 29, 2012; accepted June 21, 2012; Epub July 23, 2012; published July 31, 2012

Abstract: Objectives: We reported cases of amnestic mild cognitive impairment (MCI) without the core clinical features
of dementia with Lewy bodies (DLB) (dementia and spontaneous parkinsonism) with low uptake in
123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy. Methods: During a 3-year period at a university clinic,
we had 254 patients with memory complaints; 106 men, 148 women; mean age 72.5 years (48-95 years). In all
patients we performed neurologic examination; memory tests including the MMSE, ADAScog, FAB and additional
WMS-R; and imaging tests including brain MRI, SPECT and MIBG scintigraphy. Results: The criteria of amnestic MCI
were fulfilled in 44 patients; and 13 of them (30%) showed low MIBG uptake. They had the following: uniformly elderly,
with an equal sex ratio, have relatively slow progression, preserved general cognitive function (MMSE 24.8/30). In
addition to memory impairment, they commonly showed low frontal function by FAB (12.5/18) and some had mild
visual hallucination (5). Other than memory disorder, they had autonomic disorder (nocturia in 7, constipation in 2,
postural hypotension in one), REM sleep behavioral disorder (in 3) and occipital hypoperfusion by SPECT (in 5).
Conclusion: This cohort of multidomain amnestic MCI cases may present with early stage DLB because of the
presence of low MIBG uptake. Clinically, they commonly have low FAB, and may have visual hallucination, autonomic
and sleep disorders. (AJND1204008).

Keywords: memory disorder, amnestic mild cognitive impairment, dementia with Lewy bodies,
metaiodobenzylguanidine (MIBG) myocardial scintigraphy


Address all correspondence to:
Ryuji Sakakibara, MD, PhD
Neurology, Internal Medicine
Sakura Medical Center, Toho University
564-1 Shimoshizu, Sakura, 285-8741 Japan.
Phone: +81-43-462-8811 ext.2323; FAX: +81-43-487-4246
E-mail: sakakibara@sakura.med.toho-u.ac.jp