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Am J Neurodegener Dis 2013;2(2):140-144

Original Article
Clinical outcomes and serum uric acid levels in elderly patients with
amyotrophic lateral sclerosis aged ≥ 70 years

Hiroshi Kataoka, Takao Kiriyama, Yasuyo Kobayashi, Hirosei Horikawa, Satoshi Ueno

Department of Neurology, Nara Medical University, Kashihara, Nara, Japan; Department of Physical Medicine,
Rehabilitation Nara Medical University, Kashihara, Nara, Japan

Received April 15, 2013; Accepted May 10, 2013; Epub June 21, 2013; Published July 1, 2013

Abstract: Background: Amyotrophic lateral sclerosis is a slowly progressive fetal neurodegenerative disease in which
clinical phenotype and nutritional status are considered prognostic factors. Advanced age has also been reported to
carry a poor prognosis in amyotrophic lateral sclerosis. The elderly population is expected to increase in Japan, as
well as in other countries in the near future. Whether late-onset amyotrophic lateral sclerosis affects the average
lifespan or survival of patients and the nutritional status was related to survival remains an open question. Methods:
We studied the survival of elderly 34 patients with clinically definite amyotrophic lateral sclerosis aged ≥ 70 years and
investigated serum triglycerides, cholesterol, LDL/HDL ratio, and glucose. Serum uric acid was examined. Results:
The average age at respiratory disorders or death as a whole was 77.5 ± 4.3 years. Survival did not differ significantly
between different clinical phenotypes or between patients with and those without riluzole usage. Survival differed
significantly between patients with and those without other complications. No biochemical parameter is correlated with
outcome in this series, including elevated triglyceride or cholesterol levels and an increased LDL/HDL ratio. The
survival correlated with the serum uric acid level (r = 0.407, p = 0.017). Conclusions: The onset of amyotrophic lateral
sclerosis at ≥ 70 years of age might not be the key determinant of survival in patients with amyotrophic lateral
sclerosis. (AJND1304003).

Keywords: Amyotrophic lateral sclerosis, elderly amyotrophic lateral sclerosis, survival, nutritional status, uric acid

Address correspondence to: Dr. Hiroshi Kataoka, Department of Neurology, Nara Medical University, 840 Shijo-cho,
Kashihara, Nara 634-8522, Japan. Phone: +81-744-29-8860; Fax: +81-744-24-6065; E-mail: hk55@naramed-u.ac.jp